mrgsolve 1.5.2

• Add $EVENT block for writing code related to dosing or other events that
  are implemented through model code rather than the data set (#1230).

• Add evt::reset() and evt::reset(self) functions under the evtools
  plugin; these reset the compartments in a model; overloaded functions are
  also provided to reset and dose with bolus or infusion (#1222).

• Completed dosing functionality in evtools plugin; use evt::addl() to
  schedule additional doses through an evt::ev object; use evt::ii() to
  set the dosing interval; use evt::ss() to advance the pharmacokinetic
  system to steady state just prior to dosing; evt::cmt() sets the compartment
  number; evt::amt() sets the dose amount; evt::rate() sets the infusion
  rate; see the user guide for the specific signatures that are available
  (#1227).

• Add evtools model to modlib(), illustrating how to implement dosing
  regimens from inside the model a few different ways (#1230).

• Added more comprehensive checking for duplicate blocks in a model file;
  duplicate blocks are always handled when allowed; an error message is always
  issued when duplicates are not allowed (#1238).

• Code to audit $ODE (or $DES) code, looking for an equation for every
  model compartment was refactored to use a common approach for both traditional
  models and models written with the nm-vars plugin; regardless of approach,
  the user will be warned if mrgsolve does not detect code relevant to every
  model compartment; the audit system can be bypassed by including the
  @!audit block option to $ODE (#1235).

• The autodec plugin was lightly refactored to avoid false positive detection
  of variables declared as double; plans are in place to narrow the
  scope of what is detected for declaration in future releases (#1234).

• R help files (.Rd) reviewed and revised for consistency and formatting
  (#1246).

mrgsolve 1.5.1

• Fixed yaml_to_cpp() example code to prevent saving the file to the working
  directory (#1220).

mrgsolve 1.5.0

• New functions mwrite_yaml() and mwrite_cpp() can write a model object back
  to a file, accounting for all updates since the model was read from native
  mrgsolve format using mread() (#1213).

• New function mread_yaml() for reading back models written out with
  mwrite_yaml() (#1213).

• New functions in evtools plugin: evt::replace() works like evt::bolus(),
  but will replace the amount in a given compartment rather than add to it
  (#1203).

• The nm-vars plugin now exposes DEXP(), LOG10(), COS() and SIN()
  for use in the mrgsolve C++ code blocks (#1199).

• An error is now generated when KA is equal to CL/VC while simulating from
  the one-compartment model with analytical solution invoked through
  $PKMODEL (#1179, #1197).

Bugs Fixed

• A bug was fixed when certain data frame inputs were passed to as_data_set()
  (#1115, #1196).

mrgsolve 1.4.2

• An error will now be issued at simulation time when simulation data sets
  (data and idata) contain non-numeric data in columns sharing names with
  parameters; non-numeric data in columns with certain reserved names
  (like AMT, RATE, II, ADDL, etc.) will also result in an error
  (#1193).

mrgsolve 1.4.1

• Fix bug in evt::regimen.ii(double) where timing of next dose
  was not as expected (#1170).

mrgsolve 1.4.0

mrgsolve 1.4.0

• evtools is a new plugin providing API for dynamic dosing from within the
  model; functions and classes are in the evt namespace (#1149).

• regimen is a new class located in the evt namespace via the evtools
  plugin; regimen objects can execute doses in a regular regimen (#1156).

• mread() and mcode() no longer print a message before the required
  waiting period on model recompile (#1145).

• ev_rep() output rownames are cleaned up before returning (#1158).

• C++ model code blocks (GLOBAL, PREAMBLE, MAIN/PK, ODE/DES, TABLE/ERROR) are
  now checked for <object>.<attribute> syntax; if found, symbols on both sides
  of the dot become reserved words when loading and compiling that model;
  specifically, an error will be generated if either side of the dot (<object>
  or <attribute>) is found in parameter names, compartment names, ETA labels,
  or EPS labels (#1159).

• ETA values are always simulated from OMEGA, even when the user requests they
  get scraped from data or idata via etasrc argument to mrgsim(); this
  ensures EPS are reproducible for model runs where etasrc = "omega"
  (default, ETA are simulated) or, for example, where etaasrc = "data.all"
  (scrape ETA from the data set) (#1163).

Bugs Fixed

• Fixed a bug where modeled doses scheduled to happen now were ignored if the
  time attribute was set to a value prior to the current simulation time
  (#1152).

• Fixed a bug in how doses were computed using the until argument to ev()
  (#1154).

mrgsolve 1.3.0

• The evdata object for modeled events now contains a check_unique member;
  when set to false, the event will be processed without checking for a
  matching record in the modeled event log (#1119).

• The amt attribute in evdata modeled event objects is now considered
  when looking for duplicate records in the modeled event log (#1119).

Bugs Fixed

• Fixed a bug where multiple lagged doses given at the same time but with
  different bioavailability were all given the bioavailability of the
  last dosing record (#1129, #1130).

• Fixed a bug where modeled infusions given now were never turned
  off (#1131).

• Fixed a bug where the self object (type: databox) could not be
  passed into functions written into header files that were included
  through $INCLUDE; these header files are now included immediately
  preceding any user code written into $GLOBAL (#1125, #1126).

• Fixed a bug where modeled event log was not getting reset after
  simulating the first individual; this resulted in events not getting
  executed in subsequent individuals when matching events were executed
  in the first individual; this affects modeled events only, not events
  coming from the data set (#1117, #1118).

• Fixed a bug in detecting which compartments are receiving doses
  (#1112, #1113).

mrgsolve 1.2.0

• Data set records at the same time within individual will receive different
  EPS draws; this is a change from previous behavior where records with the
  same time received the same value for EPS (#1110).

mrgsolve 1.1.1

• Remove .x from matlist documentation object per new NOTE output from
  rdevel (#1103, #1104).

mrgsolve 1.1.0

• Add new functionality for assessing consistency between names on input data
  set and parameter names (#1078).

  • New function check_data_names() executes the check.
  • New model specification block $INPUT for marking parameters as "inputs"
    and expecting them to be present in the data when check_data_names() is
    called.
  • New $PARAM block attributes @input and @tag for adding tags to
    parameters which will be checked when check_data_names() is called.
  • New function param_tags() to list parameters and tags for a given model.

• Now checking TIME and time when assessing upper / lower case name
  consistency of input data sets (#1099).

• ETAs can now be passed via idata by passing eta_src as either idata
  or idata.all to mrgsim() (#1092).

• Internal refactor of mechanics checking for user interrupt during simulation
  (#1088).

• Minor re-factor of mrgsim_nid() and documentation update to be in line
  with original intent; no meaningful change in functionality (#1086).

• parameter_list objects can now be passed to param() (#1076).

• ev_rx() syntax gains & operator allowing specification of multiple events
  at a single time (#1072).

• Kyle Meyer added as contributor (#1095).

• modlib() model 1005 re-coded to reflect the "traditional" model
  specification syntax (#1069).

• The model object update() method will again issue a warning when
  unrecognized arguments are passed (#1068).

Bugs Fixed

• Fixed bug where ETA in the first column of data was not recognized when
  using eta_src = "data" or eta_src = "data.all" (#1095).