Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

Sign up for GitHub

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Jump to bottom

Error in calcDNAmTL resulting in wrong estimates for the DNAmTL clock #8

Open
ausrinesv opened this issue Oct 16, 2023 · 0 comments
Open

Error in calcDNAmTL resulting in wrong estimates for the DNAmTL clock #8

ausrinesv opened this issue Oct 16, 2023 · 0 comments

Comments

@ausrinesv
Copy link

There seems to be an error in calcDNAmTL().

The code subtracts the intercept from the product of beta values and coefficients:

methylCIPHER/R/calcDNAmTL.R

Line 43 in e62937e

DNAmTL <- as.numeric(rowSums(tt,na.rm=T)-7.924780053)

However, in the related Supplementary Data 1 of the Lu, A. T. et al. (2019) DNA methylation-based estimator of telomere length that intercept is positive.
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Assignees
No one assigned
Labels
None yet
Projects
None yet
Milestone
No milestone
Development

No branches or pull requests
1 participant
@ausrinesv