DESCRIPTION

Package: EpiSCORE
Title: Epigenetic cell-type deconvolution with Single-Cell Omic References
Version: 0.9.5
Description: EpiSCORE is an R package to construct a tissue specific DNA methylation (DNAm) reference matrix starting out from a corresponding tissue specific scRNAseq atlas. With the DNAm reference matrix one can then estimate fractions for the main cell types present in the reference matrix in a bulk-tissue sample for which a genome-wide DNAm profile exists. In this package we provide the first installment of a DNAm-atlas containing DNAm reference matrices for 13 tissue-types. In addition, the package allows inference of cell type specific differential DNAm in the context of a general epigenome-wide association study.
Date: 2022-3-15
Author: Andrew E. Teschendorff <andrew@picb.ac.cn>
Maintainer: Andrew E. Teschendorff <andrew@picb.ac.cn>
Depends: R (>= 3.6)
Imports: org.Hs.eg.db, AnnotationDbi, MASS, parallel, presto
Suggests: EpiDISH, BiocStyle, knitr, rmarkdown, Biobase
VignetteBuilder: knitr
License: GPL-2
LazyData: true
URL: https://github.com/aet21/EpiSCORE
RoxygenNote: 7.0.2